11-13 December 2019
ILL4
Europe/Paris timezone

Probing the internal structure of nanoparticles for mRNA delivery

12 Dec 2019, 09:30
30m
Chadwick Amphitheatre (ILL4)

Chadwick Amphitheatre

ILL4

Invited contribution Session C

Speaker

Aleksandra Dabkowska (Advanced Drug Delivery, Pharmaceutical Sciences, R&D, AstraZeneca, Gothenburg, Sweden )

Description

New therapeutic modalities, such as RNA-based drugs, have shown promising results in treating diseases that are currently difficult to tackle with standard small molecule drugs. One type of RNA therapeutic, mRNA, is especially promising due to its ability to induce protein production in target cells, where it can replace damaged or missing proteins. However, clinical progress is often limited by the mRNA molecule’s innate properties: a large size, hundreds of negative charges and a propensity for rapid degradation in serum. Hence, successful application usually requires an advanced delivery system. Lipid nanoparticles (LNPs) are among the most advanced delivery vehicles for mRNA. Physico-chemical characterization of mRNA-containing LNPs reveal a structured core enveloped by a defined outer shell. By varying LNP size and surface composition we demonstrated that both size and structure have significant influence on intracellular protein production. To design better LNPs for improved therapies, we seek to understand how specific components affect the structure of these nanoparticles as well as their function.

Primary author

Aleksandra Dabkowska (Advanced Drug Delivery, Pharmaceutical Sciences, R&D, AstraZeneca, Gothenburg, Sweden )

Co-authors

Marianna Yanez Arteta (Advanced Drug Delivery, Pharmaceutical Sciences, R&D, AstraZeneca, Gothenburg, Sweden ) Lennart Lindfors (Advanced Drug Delivery, Pharmaceutical Sciences, R&D, AstraZeneca, Gothenburg, Sweden )

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