CANCELLED : Algorithms for integrative structural biology

Session

Session 1

16 Mar 2020, 09:15

ILL4/rdc-1 - Amphi Chadwick (ILL4)

19. DECOMPOSITION OF EVOLVING SAXS DATASETS USING CHEMOMETRICS

Dr Amin SAGAR (Centre de Biochimie Structurale)

Oral

Many biologically important systems are inherently polydisperse e.g. transient protein-protein complexes, oligomerizing proteins or proteins with different co-existing conformations. Such systems are always in an equilibrium of different species and are therefore heterogenous. Importantly, such systems can’t be meaningfully studied in a holistic sense by physically separating the components of...

23. Integrative methods to study flexible multi-domain enzymes: an experimental approach

Maria Marcaida (EPFL)

Oral

Integrative modeling is a powerful tool to study the structure-function relationship in multi-domain flexible systems. Here we will describe the combination of modelling, solution scattering data and flexible fitting as well as biochemical and biophysical analyses that have been used to define the quaternary structure of DDX21, a human DEAD-box helicase with RNA G-quadruplex resolving...

31. Modeling the Solution State through SAXS

Robert Rambo (Diamond Light Sourcwe)

Oral

Understanding how proteins and complexes move in solution remains a major challenge in structural biology. Biological macromolecules are machines that adopt a variety of structural conformations and efficiently exploring this structural space in a comprehensive and meaningful way can not be achieved solely using the solid-state methods cryo-EM and macromolecular crystallography (MX). Small...