Neurodegenerative diseases are very complex and a holistic understanding of the relation between structure and function requires the integration of molecular, cellular and systems biology. We applied ‘omic' technologies to generate of a most complete protein interactome associated with Alzheimer’s disease (1). The analysis of this network triggered insights on the mechanisms implicated in the...
Pathogens often evolve methods of modulating host cell signalling pathways in order to promote their growth and persistence in the infected cell. One of the most efficient methods to interact with host signalling proteins is the use of intrinsically disordered proteins combined with short linear motifs, as the evolutionary timescales involved are shorter than those required for globular...
Electrostatic interactions play a pivotal role in many (bio)molecular association processes. The molecular organization and function in biological systems are largely determined by these interactions from pure Coulombic contributions to more peculiar mesoscopic forces due to ion-ion correlation and proton fluctuations. By means of constant-pH Monte Carlo simulations based on a fast...