Recent breakthroughs in X-ray crystallography, Cryo-EM and complementary approaches resulted in elucidation of many new structures of membrane proteins (MPs) and their complexes. Several classes of MPs, such as microbial rhodopsins, rotary ATPase subunits c, or light harvesting complexes 2, form ring-like assemblies with several lipid molecules trapped inside. Whereas the proteins are usually...
Multiple protein sequence alignments are used daily in bioinformatics to annotate and predict the characteristics of currently mass produced sequences. The quality of their results have been assessed many times and have recahed a plateau. Proteins fold into stable three-dimensional structures with a topology much more conserved than sequence. Consequently, it should be advantageous to use this...
