CANCELLED : Algorithms for integrative structural biology

Session

Session 4

16 Mar 2020, 16:10

ILL4/rdc-1 - Amphi Chadwick (ILL4)

27. Assembly of membrane protein complexes with encapsulated lipids

Ivan Gushchin (Moscow Institute of Physics and Technology)

Oral

Recent breakthroughs in X-ray crystallography, Cryo-EM and complementary approaches resulted in elucidation of many new structures of membrane proteins (MPs) and their complexes. Several classes of MPs, such as microbial rhodopsins, rotary ATPase subunits c, or light harvesting complexes 2, form ring-like assemblies with several lipid molecules trapped inside. Whereas the proteins are usually...

4. Building a model of an homodimeric multi-domain protein, interacting with ssDNA and dsDNA : The challenges of RelSt3 relaxase modeling

DOMINIQUE MIAS-LUCQUIN (LORIA)

Oral

Spread of antibiotic resistance genes by conjugative mechanisms represent a major public health issue. Among the elements involved in these horizontal genes transfers, mechanisms involving integrative and conjugative elements (ICEs) are the most common. The RelSt3 relaxase is a protein that binds to a sequence-specific dsDNA, and to the ssDNA region of a hairpin to cut it prior to its...

20. How to combine sequence and structure information in multiple protein alignements?

Mathilde Carpentier (ISYEB - MNHN - SU - CNRS - EPHE)

Oral

Multiple protein sequence alignments are used daily in bioinformatics to annotate and predict the characteristics of currently mass produced sequences. The quality of their results have been assessed many times and have recahed a plateau. Proteins fold into stable three-dimensional structures with a topology much more conserved than sequence. Consequently, it should be advantageous to use this...