CANCELLED : Algorithms for integrative structural biology

Session

Session 7

17 Mar 2020, 09:00

ILL4/rdc-1 - Amphi Chadwick (ILL4)

28. Coupling X-ray crystallography and molecular modeling for the structural investigation of flexible antibody paratopes: A case study

Juan Cortés (LAAS-CNRS, Université de Toulouse)

Oral

By providing a precise snapshot of the structure of the interface between two protein partners, X-ray crystallography helps identifying point mutations that are likely to strengthen the interaction. However, this technique provides very little information about conformational flexibility, in particular in protein loop fragments. In cases where plasticity may be critical for protein function,...

26. Integrative structures of protein complexes with intrinsically disordered proteins: a case study and current challenges

Hugo van Ingen (Utrecht University)

Oral

Intrinsically disordered proteins (IDPs) are key in wide range of biological processes, from signal-transduction pathways to the protection of genomic integrity. Yet, their unstructure poses a significant challenge for understanding their function at the atomistic level. In our work we aim to decipher the role of the intrinsically disordered acidic domain of APLF (APLFAD) in binding and...

33. Using NMR and Molecular Modelling to Understand the Function of Highly Dynamics Biomolecules

martin blackledge

Oral

TBA