CANCELLED : Algorithms for integrative structural biology

Session

Session 10

Mar 17, 2020, 3:40 PM

ILL4/rdc-1 - Amphi Chadwick (ILL4)

16. Approaches to conformational heterogeneity of full antibodies by cryo-EM

David Fernandez (ESRF)

Oral

Multispecific antibodies are artificially engineered molecules designed to bind simultaneously to several different antigens. Potential advantages of generating viable multispecific antibodies include the identification of malignant cells coupled with the concurrent recruitment of immune cells and the blocking of complex viral escape mechanisms. The cross-over dual-variable immunoglobulin...

15. Deep learning approaches in single particle Cryo-Electron Microscopy

Dr Eaazhisai Kandiah (ESRF)

Oral

Over the last two decades, single-particle cryo-electron microscopy has emerged as a technique capable of producing routinely near-atomic resolution structures and render to study challenging systems that otherwise defy structural characterization. Recent technical advances in this field have resulted in breakthrough progress in its applicability to various biological macromolecules,...

3. Fragment-based docking to tackle the ssRNA flexibility

Antoine Moniot

Oral

Protein-RNA interactions are involved in many biological processes like the traduction of messenger RNA to protein, and their modelisation is important to understand them. In particular, non-paired regions of the RNA, i.e., single-stranded RNA (ssRNA), are involved in most of these interactions and are essential for their specificity.

However, ssRNAs are highly flexible and their...