CANCELLED : Algorithms for integrative structural biology

Session

Session 8

17 Mar 2020, 10:45

ILL4/rdc-1 - Amphi Chadwick (ILL4)

2. Computer simulations of intrinsically disordered proteins - What are we missing?

Dr Marie Skepö (Div. of Theoretical Chemistry, Dept. of Chemistry, Lund University, Sweden)

Oral

Intrinsically disordered proteins (IDPs) lack well-defined three-dimensional structure in solution under physiological conditions. Despite this they are functional and participate in the regulation of many biological processes, in which disorder can enable interactions of high specificity coupled with low affinity. Phosphorylation is one of the most abundant types of post-translational...

22. Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex

Adrien Favier (IBS CNRS)

Oral

Atomic-resolution structure determination is the key requirement for understanding protein function. Cryo-EM and NMR spectroscopy both provide structural information, but currently cryo-EM does not routinely give access to atomic-level structural data, and, generally, NMR structure determination is restricted to small (<30 kDa) proteins. We introduce an integrated structure determination...

14. Structural diversity and odd functions in RNA viruses.

Dr Francois FERRON (Architecture et Fonction des Macromolécules Biologiques, AFMB - CNRS)

Oral

In the recent years a massive amount of raw viral genomic data has been produced and released in sequenced databases, leading to the paradoxical situation of generating the Domain of Unknown Function (DUF), the number one domain in knowledge databases. Together with bio-informatics prediction, the knowledge of the three-dimensional structures of DUF proteins is the key to unveil the full...