The field of nanomedicine has reached a milestone since the approval of Patisiran the first ever approved siRNA drug designed to treat transthyretin (TTR) amyloidosis and that of Corminaty and Spikevax messenger RNA (mRNA)-based vaccines against COVID-19, both delivered by a lipid nanocarrier. Nucleic acids are now considered as real hope but not only hype to cure unmet medical diseases as...
Phospholipid-porphyrin conjugates (PL-Por) are amphiphilic scaffolds that consist of porphyrin derivatives grafted to a lysophosphatidylcholine backbone 1-4. Owing to their structural similarities with phospholipids, several PL-Por conjugates have shown to be able to self-assemble into liposome-like assemblies exhibiting unique photophysical properties compared to their monomeric counterparts....
Light-switchable Azo-PC lipids incorporate a photo-sensitive azobenzene unit in a phosphatidylcholine lipid. Azo-PC undergoes a reversible photo-isomerisation of cis- and trans-state upon irradiation with UV, respectively visible light. The isomerization of such momomers is well understood in good solvents such as methanol. The photo physics of assemblies in water is less well...
