Bilayers at the ILL

Session

Session A

11 Dec 2019, 14:00

Chadwick Amphitheatre (ILL4)

11. Metabolic incorporation of deuterium into nerve myelin

Daniel A. Kirschner (Boston College)

11/12/2019, 14:00

Oral presentation

Myelin sheaths are the differentiated membrane assemblies in the central and peripheral nervous systems (CNS; PNS) that wrap nerve fibers in a jelly-roll-like arrangement. The regular organization along fibers of these electrically-insulating, multilamellar, lipid-rich sheaths is responsible for the rapid conduction of electrical signals from one node of Ranvier to the next node. The...

76. Interactions in the pre-AD mimicking model membranes

Norbert Kucerka (Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research in Dubna, Russia and Department of Physical Chemistry of Drugs, Faculty of Pharmacy, Comenius University in Bratislava, Slovakia )

11/12/2019, 14:30

Invited contribution

The Alzheimer’s disease (AD) is a devastating neurodegenerative disease caused by the formation of senile plaques, primarily consisting of Amyloid-beta peptides. The crucial role in this process at its pre-clinical stage is likely imparted by peptide-membrane interactions [1], though the further details are yet to be understood. Our recent experimental data for example revealed several...

5. Lipid domain modulation and inhalation anesthesia

David Worcester (NIST Center for Neutron Research)

11/12/2019, 15:00

Oral presentation

Small membrane lipid domains are important in cell signaling. We investigate modulation of lipid domains by volatile anesthetics. Many volatile compounds produce anesthesia. With no molecular target identified, mechanisms remain puzzling. Large membrane concentrations (~100 mM) are required to produce anesthesia. Hyperbaric pressures (~100 bar) reverse anesthesia.
Using neutron/x-ray...

29. Influence of galactoglycerolipids on the chloroplast envelope outer membrane architecture and its adaptation to phosphate deprivation in plants

Stéphanie Bolik (Laboratoire de Physiologie Cellulaire et Végétale (CEA/CNRS/INRA/UGA)/ILL)

11/12/2019, 15:20

Oral presentation

Plant cell membranes glycerolipids can be classified in two groups: phospholipids containing phosphate, mainly synthesized in the endoplasmic reticulum (ER), and glycolipids – galactolipids and sulfolipids - without phosphate, synthesized in chloroplasts, and being the major constituents of photosynthetic membranes. When plants are deprived of phosphate, a frequent natural situation that...