Bilayers at the ILL

Session

Session D

12 Dec 2019, 11:00

Chadwick Amphitheatre (ILL4)

33. The rich phenomenology of glycolipids and membrane-anchored polysaccharides - Insights from scattering techniques and complementary computer simulations

Emanuel Schneck (TU Darmstadt)

12/12/2019, 11:00

Invited contribution

Biological membranes often contain considerable amounts of glycolipids or membrane-anchored polysaccharides. Both can strongly influence the membrane characteristics in terms of their interactions with ions [1] and molecular components of the aqueous medium [2], their interactions with adjacent membranes [2, 3], and their in-plane organization [1], among others. We use various scattering...

8. Using suspended bilayers as a novel bacterial membrane mimetic for investigating mechanosensitive ion channels with neutron reflectivity

Simon Titmuss (University of Edinburgh)

12/12/2019, 11:30

Oral presentation

In Gram negative bacteria, the inner membrane is suspended from a thin peptidoglycan layer and contains embedded membrane proteins. This composite layer controls the shape of the cell and the flux of materials into and out of the cell. Mechanosensitive ion channels act as safety valves, protecting bacteria from osmotic shock, by opening when the membrane is subject to a stress. In addition to...

20. Mucin thin layers on top of model membranes as a model environment for mucosal delivery

Valeria Rondelli (Università degli Studi di Milano)

12/12/2019, 11:50

Oral presentation

Mucus is a highly viscoelastic secretion, covering the epithelia surfaces of the gastrointestinal, pulmonary, oral, nasal and genital tracts. Its function and composition differs at different locations of our body, but the general task of mucus is to protect mucosal tissues from dehydration, mechanical stress, and to act as barrier against microorganisms and toxic substances. Mucus is mainly...

10. Oxidation of saturated and unsaturated bilayers by reactive oxygen species

Martin King (Royal Holloway University of London, UK)

12/12/2019, 12:10

Oral presentation

Oxidation of membrane lipids in biology is a very important field because it may impact ageing, cell apoptosis and cancer[1]. It is unclear what the chemical identity of the oxidant is and there is plenty of discussion in the literature. Consequently, the term ROS (reactive oxygen species) is invoked and that may include the oxidants OH, O$_2$($^1\Delta_g$), HO$_2$, O$_2^-$ etc. Studies of the...