Bilayers at the ILL

Session

Session H

13 Dec 2019, 11:00

Chadwick Amphitheatre (ILL4)

12. pH-induced rearrangements in lipid bilayer causing in drug release from pH-sensitive liposomes

Olga Zaborova (Lomonosov Moscow State University)

13/12/2019, 11:00

Oral presentation

The development of stimuli-sensitive, particularly pH-sensitive, liposomal nanocontainers for targeted drug delivery is of great value nowadays. The pH-sensitivity of liposomes can be achieved by embedding the pH-switcher into the lipid bilayer, thus the decrease of the pH value would result in release of the entrapped compound.
In this study we examined the pH-dependent kinetics of changes in...

46. Role of membrane sphingolipids in the interaction with amyloid beta-peptide

Rita Carrotta (CNR, Istituto di Biofisica)

13/12/2019, 11:20

Oral presentation

The early impairments appearing in Alzheimer's disease are related to neuronal membrane damage. Both,aberrant A$\beta$ species and specific membrane components play a role in promoting aggregation, deposition and signal dysfunction. Ganglioside GM1, present with cholesterol and sphingomyelin in lipid rafts, seems to be able to initiate A$\beta$ aggregation on membrane [1]. In general,...

21. Adsorption and interactions of polymer stabilised lipid nanodiscs with a bilayer at the solid-liquid interfaces

Thomas Arnold (ESS)

13/12/2019, 11:40

Oral presentation

Styrene-maleic acid lipid particles (SMALPs) are self-assembled discoidal structures composed of a polymer belt and a segment of lipid bilayer, which are capable of encapsulating membrane proteins directly from the cell membrane. In recent years a number of different nanodisc forming polymers with varying properties have been developed and characterised. For example, Styrene-maleic imide lipid...

67. Dynamic polymer-based nanodiscs for membrane biophysics

Sandro Keller (Molecular Biophysics, Technische Universität Kaiserslautern (TUK))

13/12/2019, 12:00

Invited contribution

Amphiphilic copolymers enable a fundamentally new approach for investigating membrane proteins, as they obviate the use of conventional detergents. These polymers extract proteins and surrounding lipids directly from cellular membranes to form nanosized discs, where the polymer wraps around a lipid-bilayer patch. Such nanodiscs are amenable to a broad range of methods requiring nanosized...