Speaker
Rémi Vuillemot
(LJK, Université Grenoble Alpes, France)
Description
Cryo-Electron Microscopy (cryo-EM) allows conformational studies of macromolecular complexes in their close-to-native state, essential for understanding their working mechanisms and for structure-based drug development. However, deciphering continuous conformational transitions of macromolecules, through the main cryo-EM processing techniques, Single Particle Analysis (SPA) and cryo-Electron Tomography (cryo-ET), is challenging partly due to the low signal-to-noise ratio. I will present new image processing methods based on Molecular Dynamics (MD) simulations that allow extracting continuous conformational variability from SPA and cryo-ET data.
| Submitting to: | Integrative Computational Biology workshop |
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Primary author
Rémi Vuillemot
(LJK, Université Grenoble Alpes, France)
Co-author
Slavica Jonic
(CNRS & Sorbonne University, Paris)
