Feb 12 – 16, 2024
EPN Campus
Europe/Paris timezone

Deciphering protein conformational dynamics with cryo-EM and MD simulations

Feb 13, 2024, 3:00 PM
25m
IBS seminar room (EPN Campus)

IBS seminar room

EPN Campus

71 avenue des Martyrs 38000 Grenoble

Speaker

Rémi Vuillemot (LJK, Université Grenoble Alpes, France)

Description

Cryo-Electron Microscopy (cryo-EM) allows conformational studies of macromolecular complexes in their close-to-native state, essential for understanding their working mechanisms and for structure-based drug development. However, deciphering continuous conformational transitions of macromolecules, through the main cryo-EM processing techniques, Single Particle Analysis (SPA) and cryo-Electron Tomography (cryo-ET), is challenging partly due to the low signal-to-noise ratio. I will present new image processing methods based on Molecular Dynamics (MD) simulations that allow extracting continuous conformational variability from SPA and cryo-ET data.

Submitting to: Integrative Computational Biology workshop

Primary author

Rémi Vuillemot (LJK, Université Grenoble Alpes, France)

Co-author

Slavica Jonic (CNRS & Sorbonne University, Paris)

Presentation materials

There are no materials yet.