SXNS17

Session

Biological membranes and interfaces

16 Jul 2024, 13:40

ESRF Auditorium

Conveners

Biological membranes and interfaces: Biological membranes and interfaces

• Giovanna Fragneto (EUROPEAN SPALLATION SOURCE)

101. Neutron Reflectometry and Integrative Modeling Reveal HIV-1 Nef Homodimer Formation on Model Lipid Membranes

Frank Heinrich (Department of Physics, Carnegie Mellon University, Pittsburgh, PA, United States and National Institute of Standards and Technology Center for Neutron Research, Gaithersburg, MD, United States)

16/07/2024, 13:40

Invited

Neutron reflectometry (NR) is intrinsically a low-resolution structural technique, yielding one-dimensional scattering length density profiles that are often inadequate for detailed structural biology applications. However, NR stands out as one of the few methods capable of characterizing membrane-bound proteins and protein assemblies in a biomimetic, solvent-immersed, and thermodynamically...

48. Dynamics of photoinduced bidirectional phase transitions in phospholipid membranes

Svenja Hövelmann (CAU Kiel/ DESY)

16/07/2024, 14:10

Oral

Lipid membranes are the backbone for biologicals cells and to understand intercellular, and cell-cell interaction is of fundamental interest. The lipid molecules within the membrane define the cell properties and mesophase, and influence the functionality and efficiency of membrane proteins. [1,2,3] Therefore, controlled interaction between proteins and lipids in the biological membrane yields...

39. Controlling life and death with proteins: A protein-protein interaction investigated with neutron reflectometry.

Dr Sophie AYSCOUGH (University of Lund, European Spallation Source)

16/07/2024, 14:30

Oral

Mitochondria are well known as the ‘powerhouse of the cell’. Mitochondria also play a crucial role in apoptosis, a programmed mechanism of cell death. This process is tightly regulated by proteins at the mitochondrial outer membrane (MOM).
In this mechanism of cell death, the pro-apoptotic Bax protein is attracted to the outer mitichondrial membrane (MOM), where it induces membrane leakage....

6. Assembling and rigidifying DNA macromolecules by ionic liquids

Prof. Sajal Kumar Ghosh (Shiv Nadar Institution of Eminence)

16/07/2024, 14:50

Oral

Deoxyribonucleic acid (DNA) is a negatively charged bio-macromolecule that helps in the transmission of genetic information for the growth and functioning of a living organism. Therefore, it is considered as a potential tool in gene therapeutics. Packing or condensing of this macromolecule is difficult because of the intra and intermolecular repulsive electrostatic and entropic interactions....

62. Nanostructural characterisation of glycosylated protein biomarkers interaction with lipid bilayer membranes: basis for biosensor development

Beatrice Barletti (Institut Laue-Langevin)

16/07/2024, 15:10

Oral

Plasma proteins are often used as biomarkers for severe pathologies including cancers and autoimmune diseases since they provide a circulating representation of the body conditions. Nevertheless, their detection in blood samples is still challenging due to their low abundance (pico- and nano-grams level), but mostly due to their glycosylated state which is believed to favor protein-lipid...

35. Lactofungin and Amphotericin B Synergistically Interact with Model Membranes

Stephen Holt (Australian Nuclear Science and Technology Organisation)

16/07/2024, 15:30

Oral

Invasive fungal infections (IFIs) are an underappreciated public health threat that cause > 1.6 million deaths p/a with mortality rates between 20-80% [1,2]. Amphotericin B (AmB) is one of the most effective anti-fungal drugs. It kills fungal cells by binding to ergosterol in fungal cell membranes, causing membrane permeabilisation and changes in ergosterol-dependent signalling pathways [3 4]....