Operando X-ray scattering and imaging experiments to reveal the multiscale-structure of bone scaffolds made of nanoparticles for regenerative biomaterials.

17 Dec 2025, 16:40
20m
ILL50-110 (ILL50)

ILL50-110

ILL50

71 avenue des Martyrs 38000 Grenoble

Speaker

Guillaume Brotons (Université du Mans)

Description

A new-generation of synthetic bone scaffold is tailored using a bricks-and-mortar approach from bioactive glass nanoparticles BGNps and customized polymers (PLA, poly (lactic acid), the mortar). Used as synthetic implants for substitutive and regenerative therapies targeting mandibular osteoradionecrosis (ORM). To shed light on the mechanisms behind the formation of the hierarchical structure of these scaffolds, the synthesis of BGNps was studied using in-situ SAXS at synchrotrons and thanks to a custom-built sample chamber, fast X-ray phase-contrast tomography operando experiments.

Primary author

Guillaume Brotons (Université du Mans)

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