Speaker
Fabienne Testard
(CEA, UMR 3685 CEA_CNRS, NIMBE/LIONS Université Paris Saclay)
Description
In the context of nanomedicine, combining SAXS, SANS and cryoTEM is a powerfull methodology to probe the formation, aging in biological media and interactions of Drug nanoparticles with proteins. In this talk, I will illustrate from different examples of bioconjugates self-assembled nanoparticles, how this approach allowed us to link the nanoparticle’s structure, stability, and analgesic activity [1-6].
- Saha, D., Testard, F., Grillo, I., Zouhiri, F., Desmaele, D., Radulescu, A., ... & Spalla, O. The role of solvent swelling in the self-assembly of squalene based nanomedicines. Soft matter, (2015) 11(21), 4173-4179.
- Rouquette, M., Ser-Le Roux, K., Polrot, M., Bourgaux, C., Michel, J. P., Testard, F., ... & Lepetre-Mouelhi, S.. Towards a clinical application of freeze-dried squalene-based nanomedicines. Journal of drug targeting, (2019) 27(5-6), 699-708.
- Elodie Marret Sicard, phD UPS, « Nanoprécipitation de dérivés squalénés en milieux aqueux : Influence de la formulation sur la distribution de taille et la structure interne des nanoparticules obtenues », Juil. 2019
- Gobeaux, F., Bizeau, J., Samson, F., Marichal, L., Grillo, I., Wien, F., ... & Testard, F. Albumin-driven disassembly of lipidic nanoparticles: the specific case of the squalene-adenosine nanodrug. Nanoscale, (2020) 12(4), 2793-2809.
- Caillaud, M., Gobeaux, F., Hémadi, M., Boutary, S., Guenoun, P., Desmaële, D., ... & Massaad-Massade, L. Supramolecular organization and biological interaction of squalenoyl siRNA nanoparticles. International Journal of Pharmaceutics, (2021) 609, 121117.
- Lepetre-Mouelhi, S., Gobeaux, F., Da Silva, A., Prades, L., Feng, J., Wien, F., ... & Testard, F. Leu-Enkephalin Lipid Prodrug Nanoparticles: Relationship between Nanoparticles’ Structure, Interaction with Bovine Serum Albumin, and Analgesic Activity. Chemistry of Materials, (2024) 36(2), 694-707.
