GEM2023

Session

Glycobiology

17 Mar 2023, 08:30

6. Glycobiology

Prof. Hans Wandall (University of Copenhagen, Copenhagen, DK)

17/03/2023, 08:30

28. Use of membrane mimetics to explore complex glycolipids recognition mechanisms at the surface of gram-negative bacteria

Cedric LAGURI (CNRS)

17/03/2023, 09:10

Oral

The outer membrane of Gram-negative bacteria is compositionally asymmetric with LipoPolySaccharides (LPS) covering most of the outer membrane surface, while phospholipids compose the inner leaflet. LPSs form a highly impermeable barrier and are an important factor in bacterial virulence; their high structural variability and tight assembly protect bacteria against the uptake of antimicrobials...

50. Photoswitchable azobenzene-glycoconjugates induce bidirectional switching in phospholipid monolayers and vesicles

Ms Svenja C. Hövelmann (Kiel University, Deutsches Elektronen Synchrotron Hamburg)

17/03/2023, 09:30

Oral

The role of the lipid environment within a biomembrane is of fundamental interest to understand intercellular and cell-cell interaction. The lipid molecules define not only the cell structure and geometry but also influence the functionality and self-assembly of membrane proteins and channels.[1,2] Dynamic switching behaviour of the membrane associated proteins and channels regulates the...

103. A genetic entry point to harness the untapped potential in glycobiology: from decoding functions to cancer specific targeting.

Prof. Hans H. Wandall (Faculty of Health, University of Copenhagen )

Invited

Breakthroughs in O-glycobiology have gone hand in hand with the development of new technologies, such as advancements in mass spectrometry and the facilitation of genetic engineering in mammalian cell lines. High-throughput glycoproteomics has enabled us to draw a comprehensive map of O-glycosylation, and mining this information has supported the discovery of functions related to site-specific...

9. Light-triggered reorganization of photo-Gb3 enriched membranes: influence of isomerization on Shiga toxin interaction

Dr Larissa Socrier (Max Planck Institute for Dynamics and Self-Organization)

Oral

The plasma membrane is a complex assembly of proteins and lipids that can self-assemble in transitory submicroscopic domains, commonly termed “rafts”. These dynamic structures are implicated in membrane signaling and trafficking. Artificial membranes composed of certain lipids mixed with cholesterol spontaneously phase-separate in liquid-ordered (lo) and liquid-disordered (ld) domains, which...